At the Source: Treating Heart Failure by Altering Muscle Motor Function
نویسندگان
چکیده
منابع مشابه
At the source: treating heart failure by altering muscle motor function.
A new study in Science provides proof of the principle for directly modulating the cardiac muscle’s motor, myosin, as a therapeutic target in heart failure. The human and economic tolls from heart failure (HF) are significant in both developed and undeveloped countries. Although HF can take many forms, it is most commonly associated with decreased cardiac contractility and is, therefore, referr...
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Heart failure (HF) is characterized by an impaired ability of the ventricle to fill with and eject blood commensurate with the metabolic demands and requirements of the body, and has emerged as a major cause of morbidity and mortality in the developed world. Approximately 50% of HF patients have preserved ejection fraction, and lack overt signs of systolic failure, but rather have deficits in v...
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Heart failure affects over 500,000 Canadians, and 50,000 new patients are diagnosed each year. The mortality remains staggering, with a five-year age-adjusted rate of 45%. Disease management programs for heart failure patients have been associated with improved outcomes, the use of evidence-based therapies, improved quality of care, and reduced costs, mortality and hospitalizations. Currently, ...
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Background and Objectives: Heart failure is more common in the elderly than in the general population. Among the non-drug treatments, the easiest and most comprehensible method is direct implementation of sports program. Due to high cost of hospital care for patients with heart failure and complications, this study examined the effects of walking as a form of rehabilitation program. The subject...
متن کاملChronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function.
Patients with chronic heart failure (HF) frequently lose muscle mass and function during the course of the disease. A reduction in anabolic stimuli to the muscle has been put forth as a potential mechanism underlying these alterations. The present study examined the hypothesis that skeletal muscle tissue from HF patients would show reduced IGF-1 expression and phosphorylation of signaling molec...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2011
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.0b013e31822765e2